The prognostic value of amyloid imaging.
Giorgio Gelosa1, David J Brooks
1Department of Neurology and Nuclear Medicine, University of Milano-Bicocca, Monza, Italy. giorgio.gelosa@yahoo.it
European Journal of Nuclear Medicine and Molecular Imaging
|April 12, 2012
Summary
Positron emission tomography (PET) amyloid imaging detects early Alzheimer's pathology in individuals with mild cognitive impairment. This technology aids in prognosis and clinical trial recruitment for antiamyloid therapies.
Area of Science:
- Neurology
- Nuclear Medicine
- Biomarkers
Background:
- Mild cognitive impairment (MCI) involves cognitive decline without functional impairment.
- Amnestic MCI progresses to Alzheimer's disease (AD) annually at 10-15%.
- Neuropathology in MCI often bridges normal aging and AD.
Purpose of the Study:
- To review the role of PET imaging in assessing amyloid load.
- To evaluate its utility in identifying individuals at risk for Alzheimer's disease.
- To discuss its application in cognitively normal elderly and MCI subjects.
Main Methods:
- Utilizes newly developed PET amyloid imaging agents.
- Focuses on noninvasive in vivo detection of Alzheimer's pathology.
- Discusses (18)F-labelled amyloid imaging agents for PET centers.
Main Results:
- Amyloid deposition precedes cognitive symptoms by over a decade.
- PET imaging serves as a noninvasive biomarker for early AD pathology.
- Exclusion of amyloid pathology improves prognostic accuracy.
Conclusions:
- PET amyloid imaging enables early detection of AD pathology in at-risk individuals.
- It facilitates accurate prognosis and targeted recruitment for antiamyloid clinical trials.
- (18)F-labelled agents enhance accessibility for clinical and research applications.
Related Concept Videos
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET