Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Inflammation01:38

Inflammation

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Persistent activation of monocytes/macrophages and cell senescence in SIV-infected macaques on ART.

Frontiers in immunology·2026
Same author

Coronary atherosclerotic plaque composition and classification in hypercholesterolemic pigs.

Atherosclerosis·2026
Same author

Insulin use promotes pro-inflammatory changes in the transcriptome of atherosclerotic plaques in patients with diabetes mellitus.

Journal of molecular and cellular cardiology plus·2025
Same author

Persistent Activation of Monocytes/Macrophages and Cell Senescence in SIV-Infected Macaques on ART.

bioRxiv : the preprint server for biology·2025
Same author

Immune correlates analysis of antibody responses against SARS-CoV-2 variants in the ENSEMBLE vaccine efficacy trial.

iScience·2025
Same author

IGF-1 downregulates matrix metalloproteinase 8 to promote plaque stability: Evidence from myeloid cell-specific MMP8 in atherosclerosis.

PloS one·2025

Related Experiment Video

Updated: May 23, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Aging, atherosclerosis, and IGF-1.

Yusuke Higashi1, Sergiy Sukhanov, Asif Anwar

  • 1Tulane University Heart & Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|April 12, 2012
PubMed
Summary
This summary is machine-generated.

Insulin-like growth factor 1 (IGF-1) protects against atherosclerosis and vascular aging. This review details how IGF-1 reduces oxidative stress and inflammation, improving plaque stability and vascular health.

Related Experiment Videos

Last Updated: May 23, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Area of Science:

  • Endocrinology
  • Cardiovascular Science
  • Aging Research

Background:

  • Insulin-like growth factor 1 (IGF-1) is a key growth factor with widespread effects.
  • Aging is linked to increased vascular oxidative stress and disease.
  • IGF-1 shows promise in reducing atherosclerosis and improving plaque stability in animal models.

Purpose of the Study:

  • To review the role of IGF-1 in modulating vascular oxidative stress.
  • To summarize IGF-1's effects on limiting atherogenesis.
  • To explore IGF-1's potential benefits for vascular aging.

Main Methods:

  • Literature review of studies on IGF-1, atherosclerosis, and vascular aging.
  • Analysis of proposed mechanisms for IGF-1's atheroprotective effects.
  • Synthesis of evidence regarding IGF-1's impact on oxidative stress and inflammation.

Main Results:

  • IGF-1 reduces oxidative stress, apoptosis, inflammation, and endothelial dysfunction.
  • IGF-1 lessens atherosclerosis burden and enhances plaque stability in animal models.
  • IGF-1 may counteract age-related vascular oxidative stress and disease.

Conclusions:

  • IGF-1 demonstrates significant atheroprotective properties.
  • IGF-1 holds therapeutic potential for mitigating vascular aging and its complications.
  • Further research is warranted to translate these findings to clinical applications.