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Updated: May 23, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
Published on: September 13, 2018
Hippo pathway in intestinal homeostasis and tumorigenesis
Lanfen Chen1, Funiu Qin, Xianming Deng
1State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China. chenlanfen@xmu.edu.cn
Abstract:
The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death. Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis. Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis, and the crosstalk between the Hippo signaling pathway and other major signaling pathways, i.e. Wnt, Notch and Jak/Stat signaling pathways in intestinal compartment.
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