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Serum γ-glutamyltransferase activity in patients with nonvalvular atrial fibrillation

Gulacan Tekin1, Yusuf Kenan Tekin, Dilsad Amanvermez Senarslan

  • 1Department of Cardiology, Faculty of Medicine, Bozok University, Yozgat, Turkey. gulacantekin@hotmail.com

Angiology
|April 12, 2012
PubMed

Insights

Serum gamma-glutamyltransferase (GGT) activity is significantly higher in elderly patients with chronic atrial fibrillation (AF). This finding suggests a potential link between elevated GGT levels and AF, a common heart rhythm disorder.

Area of Science:

  • Cardiology
  • Biochemistry
  • Geriatrics

Background:

  • Patients with chronic atrial fibrillation (AF) exhibit increased procoagulant and prothrombotic states.
  • Understanding biomarkers associated with AF is crucial for risk stratification and management.

Purpose of the Study:

  • To compare serum gamma-glutamyltransferase (GGT) activity between elderly patients with nonvalvular chronic AF and control participants with normal sinus rhythm.
  • To investigate the association between serum GGT activity and chronic nonvalvular AF.

Main Methods:

  • Retrospective study including 81 elderly patients with nonvalvular chronic AF and 210 age- and gender-matched controls.
  • Serum GGT activity was measured and compared between the AF and control groups.
  • Demographic and clinical characteristics were analyzed for comparability.

Main Results:

  • Serum GGT activity was significantly higher in patients with chronic AF compared to controls (P = .003).
  • Key clinical factors including coronary artery disease, hypertension, and diabetes were comparable between groups.
  • Serum GGT activity was independently associated with chronic nonvalvular AF.

Conclusions:

  • Elevated serum GGT activity is significantly associated with chronic nonvalvular AF in elderly patients.
  • GGT may serve as a potential biomarker for AF.
  • Further research is warranted to explore the clinical implications of this association.

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