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COUP-TFII controls amygdala patterning by regulating neuropilin expression.

Ke Tang1, John L R Rubenstein, Sophia Y Tsai

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. ktang_sc@yahoo.com

Development (Cambridge, England)
|April 12, 2012
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This summary is machine-generated.

The caudal ganglionic eminence (CGE) contributes cells to the amygdala. COUP-TFII is crucial for CGE cell migration and amygdala development by regulating Nrp1 and Nrp2 expression.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • The caudal ganglionic eminence (CGE) is a posterior subpallial domain in the developing telencephalon.
  • Its role in telencephalon patterning and amygdala formation is poorly understood.
  • COUP-TFII (COUP-binding transcription factor 2) is an orphan nuclear receptor highly expressed in the CGE.

Purpose of the Study:

  • To investigate the function of COUP-TFII in telencephalon development.
  • To elucidate the contribution of the CGE to amygdala complex formation.
  • To identify molecular mechanisms underlying CGE-mediated patterning.

Main Methods:

  • Generation of COUP-TFII conditional knockout mice (RxCre;COUP-TFII(F/F)).
  • Analysis of telencephalon development and amygdala formation in mutant mice.
  • Molecular analyses including gene expression, ChIP assays, and cell migration studies.

Main Results:

  • COUP-TFII deficiency caused severe defects in amygdala complex formation (LA, BLA, BMA).
  • Migration of CGE-derived Pax6(+) cells to the basomedial amygdala (BMA) nucleus was impaired.
  • Reduced expression of neuropilin 1 (Nrp1) and Nrp2 in mutants, which are direct targets of COUP-TFII.
  • Coordinated development between CGE-derived (Pax6(+)) and pallial-derived (Tbr1(+), Lhx2(+)) populations is essential for amygdala patterning.

Conclusions:

  • The CGE is a critical progenitor zone contributing cells to the basal telencephalon, including the BMA nucleus.
  • COUP-TFII plays a vital role in CGE development and neuronal migration by regulating Nrp1 and Nrp2.
  • This study reveals novel genetic insights into the coordinated development of subpallial and pallial domains for amygdala assembly.