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Related Experiment Video

Updated: May 23, 2026

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Altered interictal saccadic reaction time in migraine: a cross-sectional study.

Arjun Chandna1, Deepak P Chandrasekharan, Aravind V Ramesh

  • 1University of Cambridge, UK.

Cephalalgia : an International Journal of Headache
|April 12, 2012
PubMed
Summary

Migraineurs exhibit distinct neurological function during pain-free periods, with reduced saccadic latency variability suggesting noradrenergic system deficits. This objective method aids migraine diagnosis and research.

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Area of Science:

  • Neuroscience
  • Neurology
  • Ophthalmology

Background:

  • Migraine mechanisms are poorly understood due to a lack of objective quantitative neurological analysis methods.
  • Objective assessment of neurological function is crucial for advancing migraine research and diagnosis.

Purpose of the Study:

  • To measure interictal saccadic latency (ISL) in migraineurs and controls to identify objective neurological differences.
  • To evaluate ISL as a potential diagnostic tool for migraine.

Main Methods:

  • A cross-sectional study compared ISL distributions in 32 migraineurs and 32 matched controls.
  • Analysis included 12,800 saccades, focusing on reaction time variability and early saccade generation.

Main Results:

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Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Published on: July 14, 2016

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Last Updated: May 23, 2026

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

  • Migraineurs showed significantly reduced saccadic latency variability (σ = 1.01 vs. 1.13, p < 0.05) compared to controls.
  • A smaller proportion of migraineurs produced 'early' saccades (31% vs. 56%, p < 0.05).
  • Sensitivity/specificity analysis indicated potential for diagnostic discrimination.

Conclusions:

  • The migraineur brain exhibits significantly different behavior during interictal periods.
  • Decreased variability in ISL suggests a functional deficit in noradrenergic systems.
  • This novel ISL method is a rapid, inexpensive, objective, and quantitative tool for migraine diagnosis and research.