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Updated: May 23, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
"Accelerated ear-age": a new measure of chemotherapy-induced ototoxicity
Brian J Fligor1, Jennie D Krasker, Doojduen Villaluna
1Department of Otolaryngology and Communication Enhancement, Children's Hospital Boston, Boston, Massachusetts, USA. brian.fligor@childrens.harvard.edu
Abstract:
Currently, there are several different scales that grade chemotherapy-induced ototoxicity. This report highlights how the implications of the conclusions drawn from each scale differ and compare these prior scales to a more functionally based scale developed at Children's Hospital Boston. Additionally, this report introduces the concept of "ear-age," akin to the age at which one would expect the observed decrease in hearing as a consequence of normative aging (but documented in a child or young adult following chemotherapy).
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