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Updated: May 23, 2026

Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51
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Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex

Shang-Pu Tsai1, Guan-Chin Su, Sheng-Wei Lin

  • 1Institute of Biochemical Sciences, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei, 10617, Taiwan.

Nucleic Acids Research
|April 12, 2012
PubMed
Summary

The Swi5-Sfr1 complex physically interacts with Rad51, stabilizing its DNA-binding filament to promote homologous recombination (HR) repair. A specific motif in Sfr1 negatively regulates this crucial DNA repair process.

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