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[Cutaneous forms of Lyme borreliosis in children]
J Hercogová1, A Fadrhoncová, J Jirous
1Dermatovenerologická klinika Institutu pro dalsí vzdĕlávání lékarů a farmaceutů a fakulty dĕtského lékarství Univerzity Karlovy, Praha-Bulovka.
Insights
This study evaluated children with Lyme borreliosis skin conditions, finding serological confirmation in most cases. Antibiotic treatment was effective with no severe organ complications observed.
Area of Science:
- Pediatric Dermatology
- Infectious Diseases
- Immunology
Context:
- Lyme borreliosis presents with distinct skin manifestations in children, including erythema chronicum migrans and lymphadenosis benigna cutis.
- Accurate serological diagnosis is crucial for effective management of pediatric Lyme borreliosis.
Purpose:
- To investigate the clinical presentation, diagnosis, and treatment outcomes of skin manifestations of Lyme borreliosis in pediatric patients.
- To assess the efficacy of antibiotic treatment and identify any associated complications.
Summary:
- Thirty-seven children with skin Lyme borreliosis (31 erythema chronicum migrans, 6 lymphadenosis benigna cutis) were prospectively studied.
- Serological confirmation using ELISA with Borrelia recurrentis antigen showed increased antiborrelial antibodies in 87% of ECM and 100% of LBC cases.
- Most patients responded well to antibiotic treatment, with transient, non-specific symptoms in some; no extradermal organ complications were noted.
Impact:
- Provides insights into the clinical spectrum and diagnostic approaches for pediatric Lyme borreliosis skin manifestations.
- Highlights the generally favorable prognosis and effectiveness of antibiotic therapy in children, with an emphasis on the absence of severe systemic involvement.
Abstract:
Thirty-seven children with skin manifestations of Lyme borreliosis (31 with erythema chronicum migrans and six with lymphadenosis benigna cutis) were treated and followed up prospectivelly for 1-24 months (mean 7.58 months). The diagnosis was confirmed serologically by the finding of increased levels of antiborrelial antibodies assessed by the ELISA method, using antigen from Borrelia recurrentis, in a total of 87% patients with erythema chronicum migrans and in all patients with lymphadenosis benigna cutis. In nine patients the dermatoses were associated with general non-characteristic symptoms, after antibiotic treatment in five patients temporary fatigue, arthralgia and gastrointestinal complaints were observed. No extradermal organ complications were present. The authors discuss the clinical pictures of erythema chronicum migrans and lymphadenosis benigna cutis in children, mention diagnostic criteria and the recommended pattern of treatment.