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Updated: May 23, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
Radiosensitization of p53-deficient lung cancer cells by pre-treatment with cytostatic compounds
Sergey V Tokalov1, Nasreddin Abolmaali
1Biological and Molecular Imaging, OncoRay -- National Center for Radiation Research in Oncology, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Dresden, Germany. Sergey.Tokalov@googlemail.com
Background/Aim:
This study specifies a strategy to improve radiotherapy by partial synchronization of p53-deficient cancer cells (FaDu and H1299) in mitosis using taxol, with protecting p53 wild-type cells (A549) by the prior administration of cytostatic compounds. Cytotoxic and cytostatic effects of ionizing radiation, cisplatin, doxorubicin and taxol, administrated alone or in combination were investigated in vitro by flow cytometry.
Results:
A protective effect of doxorubicin but not cisplatin was found after administration of triple sequence with ionizing radiation and taxol. It was found that preliminary administration of doxorubicin induced growth arrest and protected A549 cells from the taxol/radiation treatment, while simultaneously killing FaDu and H1299 cells.
Conclusion:
The proposed therapeutic strategy allows protection of p53 wild-type cells and selectively increases radiosensitivity of p53-deficient cancer cells.
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