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Updated: May 23, 2026
08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Investigational ABC transporter inhibitors.
Marco Falasca1, Kenneth J Linton
1Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Diabetes, Inositide Signalling Group, 4 Newark Street, London, UK. m.falasca@qmul.ac.uk
Expert Opinion on Investigational Drugs
|April 13, 2012
Summary
Targeting ATP-binding cassette (ABC) transporters can reverse multidrug resistance (MDR) in preclinical cancer studies. However, clinical outcomes remain limited, necessitating novel inhibitors and strategies for effective cancer therapy.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Multidrug resistance (MDR) significantly hinders cancer therapy success.
- ATP-binding cassette (ABC) transporters actively efflux chemotherapy drugs, contributing to MDR.
- Emerging evidence implicates ABC transporters in cancer cell signaling pathways beyond drug resistance.
Purpose of the Study:
- To review the rationale for targeting ABC transporters in cancer treatment.
- To analyze preclinical and clinical data of ABC transporter inhibitors.
- To discuss novel strategies for overcoming MDR and the role of ABC transporters in cancer signaling.
Main Methods:
- Literature review of current research on ABC transporters in cancer.
- Analysis of preclinical and clinical trial results for ABC transporter inhibitors.
- Discussion of emerging therapeutic strategies and signaling roles.
Main Results:
- Preclinical studies show success in reversing MDR using ABC transporter inhibitors.
- Clinical trials have demonstrated limited impact on patient outcomes to date.
- ABC transporters play roles in cancer progression distinct from MDR.
Conclusions:
- Developing safe and effective ABC transporter inhibitors is crucial for improving cancer treatment.
- Current inhibitors have shown limited clinical efficacy, highlighting the need for new approaches.
- Further research into novel inhibitors and therapeutic strategies targeting ABC transporters is essential.
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