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Related Experiment Video

Updated: May 23, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

(Pro)renin and its receptors: pathophysiological implications.

Wendy W Batenburg¹, A H Jan Danser

¹Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, The Netherlands.

Clinical Science (London, England : 1979)

|April 13, 2012

Summary

This summary is machine-generated.

Tissue renin generation relies on uptake of circulating renin or prorenin. The (pro)renin receptor

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Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Published on: June 7, 2016

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Last Updated: May 23, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

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Published on: October 26, 2020

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Published on: June 7, 2016

Area of Science:

Biochemistry
Physiology
Molecular Biology

Background:

Tissue angiotensin generation is influenced by circulating renin and prorenin uptake.
The (pro)renin receptor was proposed as a mediator of this uptake, but its affinity is questionable.
Previous candidates for renin uptake include renin-binding protein and M6P/IGF2 receptor.

Purpose of the Study:

To review and critically evaluate the role of the (pro)renin receptor in (pro)renin uptake.
To compare the (pro)renin receptor with other proposed uptake mechanisms.
To discuss the implications of (pro)renin receptor blockade and knockout studies.

Main Methods:

Literature review of studies on (pro)renin receptor function and blockade.
Analysis of in vitro and in vivo experimental data.
Comparison of findings across different studies and proposed mechanisms.

Main Results:

In vitro studies show (pro)renin receptor activation leads to profibrotic effects.
The (pro)renin receptor blocker HRP showed benefits in diabetic animal models.
(Pro)renin receptor knockout studies resulted in lethal, (pro)renin-independent consequences, suggesting a role in vacuolar H+-ATPase stability.

Conclusions:

The in vivo interaction between (pro)renin and its receptor may be limited to (pro)renin-synthesizing organs like the kidney.
The (pro)renin receptor's proposed role in mediating circulating (pro)renin uptake is uncertain.
Further research is needed to clarify the precise function of the (pro)renin receptor and the effects of its blockade.