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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Organization of Genes02:07

Organization of Genes

Overview

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Related Experiment Video

Updated: May 23, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

InterStoreDB: a generic integration resource for genetic and genomic data.

Christopher G Love1, Ambrose E Andongabo, Jun Wang

  • 1Ludwig Institute for Cancer Research, Centre for Medical Research, Royal Melbourne Hospital, Royal Parade, Parkville, Victoria 3050, Australia. chris.love@ludwig.edu.au

Journal of Integrative Plant Biology
|April 13, 2012
PubMed
Summary

InterStoreDB integrates plant population, trait, genetic map, and quantitative trait loci (QTL) data. This database suite aids agricultural research by linking phenotypic traits to genomic regions for improved crop breeding.

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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

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Published on: August 15, 2019

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Area of Science:

  • Agricultural research
  • Genomics
  • Bioinformatics

Background:

  • Associating phenotypic traits with quantitative trait loci (QTL) in plant genomes is crucial for agricultural research.
  • Existing data management systems often lack integration across diverse biological domains, hindering comprehensive analysis.

Purpose of the Study:

  • To introduce InterStoreDB, an integrated database suite designed to facilitate the association of phenotypic traits with genomic regions.
  • To provide a transparent framework for navigating genetic and genomic data, including functional gene annotation and sequence data.

Main Methods:

  • Development of species-independent databases: CropStoreDB (population, genetic map, QTL, trait data), SeqStoreDB (sequence data), and AlignStoreDB (sequence alignment).
  • Integration of metadata, including data provenance and analysis parameters, for evaluating data reliability.
  • Implementation of visualization tools like CMAP for genetic maps and an EnsEMBL-based genome browser for functional annotation.

Main Results:

  • InterStoreDB provides access to curated datasets for plant populations, traits, genetic maps, marker loci, and QTL.
  • The system links genetic and genomic data, enabling navigation between different biological domains within a single portal.
  • Demonstrated utility of InterStoreDB as a valuable tool for Brassica research.

Conclusions:

  • InterStoreDB offers a unified platform for managing and analyzing complex genetic and genomic data in agricultural research.
  • The integrated approach enhances the ability to identify causative genomic regions for desired phenotypic traits.
  • The framework promotes transparency and data provenance, improving the reliability of QTL-trait associations.