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Related Experiment Video

Updated: May 23, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Acquired optic nerve and peripapillary pits in pathologic myopia.

Kyoko Ohno-Matsui1, Masahiro Akiba, Muka Moriyama

  • 1Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan. k.ohno.oph@tmd.ac.jp

Ophthalmology
|April 13, 2012
PubMed
Summary

Pit-like optic nerve (ON) pits are common in high myopia, affecting 16.2% of eyes. These ON pits, often near the optic disc or myopic conus, are best visualized with swept-source optical coherence tomography (OCT).

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Imaging

Background:

  • High myopia is associated with various pathological changes in the posterior segment of the eye.
  • Optic nerve (ON) pits are rare congenital anomalies, but their prevalence in high myopia is not well-established.
  • Pit-like structures around the optic disc and myopic conus may represent variations or pathologies.

Purpose of the Study:

  • To determine the incidence and describe the characteristics of pit-like structures in the optic disc and myopic conus regions in eyes with high myopia.
  • To compare these findings with those in emmetropic eyes.

Main Methods:

  • A prospective, observational case series design was employed.
  • 198 eyes of 119 patients with high myopia (spherical equivalent >-8 D) and 32 emmetropic eyes were evaluated.
  • Swept-source optical coherence tomography (OCT) with a 1050 nm center wavelength was used to examine the papillary and peripapillary areas and characterize pit-like changes.

Main Results:

  • Pit-like clefts were identified in 16.2% (32/198) of highly myopic eyes, but none in emmetropic controls.
  • Eyes with pits exhibited higher myopia, longer axial lengths, and larger optic discs.
  • Pits were classified as optic disc pits (11 eyes) or conus pits (22 eyes), with associated lamina cribrosa discontinuities or scleral changes.

Conclusions:

  • Optic nerve pits are a relatively common finding in eyes with high myopia.
  • These pit-like structures are often subtle ophthalmoscopically but are readily detectable using swept-source OCT.
  • The findings suggest distinct origins for optic disc pits and conus pits in the context of high myopia.