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Optimizing Tubulin Yield from Porcine Brain Tissue
Published on: October 11, 2024
Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: pyridazines
Clemens Lamberth1, Stephan Trah, Sebastian Wendeborn
1Syngenta Crop Protection AG, Crop Protection Research, Schaffhauserstr. 101, CH-4332 Stein, Switzerland. clemens.lamberth@syngenta.com
Abstract:
Special tetrasubstituted pyridazines are potent fungicides by promoting the tubulin polymerisation, hereby disrupting the microtubule dynamics in the fungus. They are monocyclic analogs of similar substituted triazolopyrimidines and pyridopyrazines with the same mode of action. The fungicidal activity of these pyridazines was evaluated against the plant pathogens Botrytis cinerea (grey mould), Mycosphaerella graminicola (wheat leaf blotch) and Alternaria solani (potato and tomato early blight). Structure-activity relationship studies revealed the importance of a methyl and a chlorine substituent next to both ring nitrogen atoms and two aryl or heteroaryl groups in the other two pyridazine positions.
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