Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Differences in T-cell Densities and Neighborhood Patterns in Human Colorectal Adenomas and Sessile Serrated Lesions.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026

Same author

Differences in T-cell counts and neighborhood patterns in human colorectal adenomas and sessile serrated lesions.

bioRxiv : the preprint server for biology·2026

Same author

Novel protein targets for type 2 diabetes prevention and their mediating role in the diet-disease relationship: evidence from 2 population-based cohorts and a Mendelian randomization analysis.

The American journal of clinical nutrition·2025

Same author

Tissue gene expression analysis approach in a context of high technical and biological heterogeneity.

BMC research notes·2025

Same author

Tissue gene expression analysis approach in a context of high technical and biological heterogeneity.

Research square·2025

Same author

Circulating proteins and incident myocardial infarction: appraising sex-specific differences and causality.

European heart journal·2025

Search research articles

Related Experiment Video

Updated: May 23, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Screening for cancer with molecular markers: progress comes with potential problems.

¹Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7555, USA. jabaron@med.unc.edu

Nature Reviews. Cancer

|April 13, 2012

Summary

New molecular biomarker tests promise accurate cancer screening. However, their implementation and interpretation pose unique challenges for clinicians and diagnosis.

More Related Videos

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

Related Experiment Videos

Last Updated: May 23, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

Area of Science:

Oncology
Biomarker Discovery
Clinical Diagnostics

Background:

Traditional cancer screening methods have limitations in sensitivity and specificity.
Emerging molecular biomarkers offer potential for more accurate and user-friendly cancer detection.

Purpose of the Study:

To discuss the potential clinical value of molecular biomarker screening for cancer.
To identify and analyze the unique implementation and interpretation challenges associated with these novel screening tests.

Main Methods:

This essay presents a conceptual analysis and discussion.
It synthesizes current research on molecular biomarkers and their clinical application.

Main Results:

Molecular biomarker screening tests are expected to be highly sensitive and specific.
These tests may be simpler to administer than existing screening modalities.

Conclusions:

While molecular biomarkers hold significant promise for cancer screening, their clinical integration requires careful consideration of implementation and interpretation issues.
Addressing these challenges is crucial for effective diagnosis and patient management.