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Related Concept Videos

Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Connective Tissue Fibers and Ground Substance01:17

Connective Tissue Fibers and Ground Substance

One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...

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Related Experiment Video

Updated: May 23, 2026

Dissection and Isolation of Region-Specific Decellularized Lung Tissue
05:25

Dissection and Isolation of Region-Specific Decellularized Lung Tissue

Published on: September 29, 2023

Extracellular matrix composition in COPD.

Raquel Annoni1, Tatiana Lanças, Ryan Yukimatsu Tanigawa

  • 1Dept of Pathology, University of São Paulo Medical School, São Paulo, Brazil. rqannoni@yahoo.com.br

The European Respiratory Journal
|April 13, 2012
PubMed
Summary
This summary is machine-generated.

Chronic obstructive pulmonary disease (COPD) alters lung extracellular matrix (ECM) composition, affecting airway structure. These ECM changes in COPD patients may contribute to persistent airflow obstruction.

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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
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Last Updated: May 23, 2026

Dissection and Isolation of Region-Specific Decellularized Lung Tissue
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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Biochemistry

Background:

  • The extracellular matrix (ECM) is crucial for maintaining lung structure and function.
  • Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow obstruction and lung tissue remodeling.
  • Understanding ECM alterations in COPD is vital for developing targeted therapies.

Purpose of the Study:

  • To investigate differences in lung ECM composition between COPD patients, smokers without COPD, and non-smoking controls.
  • To correlate ECM component changes with lung function parameters in COPD patients.

Main Methods:

  • Quantitative analysis of fractional areas of key ECM components (elastic fibers, collagens, proteoglycans, glycoproteins) in lung tissue compartments.
  • Comparison of ECM composition across three subject groups: COPD patients, non-COPD smokers, and non-smokers.
  • Statistical correlation analysis between ECM components and pulmonary function tests.

Main Results:

  • COPD patients exhibited widespread ECM alterations across large airways, small airways, and lung parenchyma compared to controls.
  • Elevated elastic fiber fractional area was observed in non-obstructed smokers.
  • Reduced type-I collagen and versican, alongside increased fibronectin and tenascin, were noted in COPD patients, correlating with lung function.
  • Significant correlations were found between elastic fibers, fibronectin, and lung function parameters in COPD.

Conclusions:

  • Lung ECM composition is significantly altered in COPD patients across all lung compartments.
  • These widespread ECM changes, including alterations in elastic fibers, collagens, and glycoproteins, likely contribute to the persistent airflow obstruction characteristic of COPD.
  • Further research into ECM remodeling in COPD may reveal novel therapeutic targets.