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Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility?

Gautier Chene1, Frédérique Penault-Llorca, Anne Tardieu

  • 1Department of Histopathology, Centre Jean Perrin, Clermont-Ferrand 63000, France.

Obstetrics and Gynecology International
|April 13, 2012
PubMed

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Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
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