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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Cyclodextrin-containing polymers: versatile platforms of drug delivery materials.
Jeremy D Heidel1, Thomas Schluep
1Calando Pharmaceuticals, Inc., 225 South Lake Avenue, Suite 300, Pasadena, CA 91101, USA.
Journal of Drug Delivery
|April 13, 2012
Summary
Cyclodextrin-containing polymers (CDPs) offer advanced nanoparticle drug delivery systems. These platforms, Cyclosert and RONDEL, enhance drug circulation, efficacy, and safety, with several candidates in clinical trials.
Area of Science:
- Polymer Chemistry
- Nanomedicine
- Drug Delivery
Background:
- Nanoparticles are crucial for improving drug circulation, biodistribution, efficacy, and safety.
- Cyclodextrin-containing polymers (CDPs) represent a significant class of nanoparticles for therapeutic applications.
Purpose of the Study:
- To review the molecular architecture, properties, and clinical progress of CDP-based nanoparticle platforms.
- To explore the Cyclosert (covalent drug attachment) and RONDEL (noncovalent nucleic acid inclusion) platforms.
Main Methods:
- Review of CDP molecular designs, including Cyclosert and RONDEL platforms.
- Analysis of physicochemical and biological properties of CDP nanoparticles.
- Examination of clinical evaluation data for leading drug candidates.
Main Results:
- CDPs can incorporate therapeutics via covalent prodrug attachment (Cyclosert) or noncovalent inclusion of nucleic acids (RONDEL).
- Both platforms demonstrate favorable nanoparticle characteristics and have advanced drug candidates into clinical trials.
Conclusions:
- CDP-based nanoparticles show significant promise in advanced drug delivery.
- Future research directions and product candidates based on CDP technology are anticipated.
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