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Related Concept Videos

Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
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Viruses with RNA Genomes

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Articles linked to this work by shared authors, journal, and citation graph.

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[Synthesis and biological properties of α-thymidine 5'-aryl phosphonates].

Bioorganicheskaia khimiia·2015
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[Bicyclic furano[2,3-D] derivatives of pyrimidine nucleosides--synthesis and antiviral properties].

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[New furano- and pyrrolo[2,3-d]pyrimidine nucleosides and their 5'-triphosphates: synthesis and biological properties].

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[Synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives].

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Natural antioxidant L-carnosine inhibits LPO intensification in structures of the auditory analyzer under conditions of chronic exposure to aminoglycoside antibiotics.

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Related Experiment Video

Updated: May 23, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
08:46

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

[4'-C-modified nucleosides: synthesis and antiviral properties].

L A Aleksandrova

    Bioorganicheskaia Khimiia
    |April 14, 2012
    PubMed
    Summary

    This review covers synthetic routes for 4'-C-modified nucleosides and their structure-activity relationships against the hepatitis C virus (HCV). These modified nucleosides show potential as antiviral agents for HCV infection.

    Area of Science:

    • Medicinal Chemistry
    • Organic Synthesis
    • Virology

    Context:

    • Hepatitis C virus (HCV) poses a significant global health challenge.
    • Nucleoside analogs are a key class of antiviral drugs.
    • Development of novel antiviral strategies against HCV is ongoing.

    Purpose:

    • To review synthetic methodologies for 4"-C-modified nucleosides.
    • To analyze the structure-activity relationships (SAR) of these compounds against HCV.
    • To provide insights into the development of new anti-HCV therapeutics.

    Summary:

    • This review consolidates information on the synthesis of 4"-C-modified nucleosides.
    • It examines how structural modifications influence antiviral activity against HCV.
    • Key synthetic approaches and SAR findings are discussed.

    More Related Videos

    Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
    15:22

    Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

    Published on: April 3, 2014

    Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
    06:34

    Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

    Published on: June 20, 2014

    Related Experiment Videos

    Last Updated: May 23, 2026

    Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
    08:46

    Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

    Published on: July 26, 2018

    Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
    15:22

    Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

    Published on: April 3, 2014

    Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
    06:34

    Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

    Published on: June 20, 2014

    Impact:

    • Highlights promising 4"-C-modified nucleosides as potential drug candidates for HCV.
    • Informs future drug design and development for hepatitis C treatment.
    • Contributes to the understanding of nucleoside analog mechanisms against viral targets.