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Bovine Mammary Gland Biopsy Techniques

Bovine Mammary Gland Biopsy Techniques

Published on: December 23, 2018

Combining quantitative trait loci and heterogeneous microarray data analyses reveals putative candidate pathways

A M Lewandowska-Sabat¹, J Günther, H M Seyfert

¹Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, NO-0033, Oslo, Norway. anna.sabat@nvh.no

Animal Genetics

|April 14, 2012

Summary

This summary is machine-generated.

This study integrates cattle genomic and pathogen transcriptomic data to identify immune pathways involved in mastitis. Key findings highlight the IL-17 and IL-8 signaling pathways

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

Veterinary Immunology
Dairy Science
Genomics

Background:

Mastitis poses a significant economic challenge to the global dairy industry.
Effective control strategies require a deeper understanding of host-pathogen interactions and immune responses.
Previous research has focused on individual aspects of mastitis, necessitating an integrated approach.

Purpose of the Study:

To identify candidate molecular pathways involved in cattle's immune response to mastitis.
To integrate genomic and transcriptomic data for a comprehensive analysis.
To uncover potential targets for improving mastitis resistance in dairy cattle.

Main Methods:

Genome-wide association mapping (GWAS) data from cattle.
Transcriptomic data from microarray studies of mastitis pathogens and host responses (in vitro and in vivo).
Bioinformatic analyses using Ingenuity Pathway Analysis (IPA) and Database for Annotation, Visualization and Integrated Discovery (DAVID).

Main Results:

Integration of genomic and transcriptomic data revealed several candidate immune pathways.
The Interleukin-17 (IL-17) and Interleukin-8 (IL-8) signaling pathways were identified as particularly significant.
These pathways are crucial for inflammatory cell recruitment and migration during infection.

Conclusions:

The IL-17 and IL-8 signaling pathways are key players in the bovine immune response to mastitis.
These findings provide a foundation for further functional studies to identify genetic factors conferring mastitis resistance.
This research contributes to developing novel strategies for mastitis control in dairy herds.