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Related Experiment Video

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In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

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PHLDA2 is an imprinted gene in cattle.

K M Sikora¹, D A Magee, E W Berkowicz

¹Genetics and Biotechnology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland.

Animal Genetics

|April 14, 2012

Summary

Genomic imprinting influences mammalian development. This study confirms PHLDA2 is a maternally expressed imprinted gene in cattle, impacting fetal tissues and the placenta.

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Area of Science:

Epigenetics
Genomics
Developmental Biology

Background:

Genomic imprinting is an epigenetic phenomenon in placental mammals, causing parent-of-origin-specific gene expression.
The PHLDA2 gene is known as a maternally expressed imprinted gene in humans, mice, and pigs.
Disruption of imprinted genes can lead to growth abnormalities, as seen in cloned mammals.

Purpose of the Study:

To investigate the expression pattern of the PHLDA2 gene in cattle.
To determine if PHLDA2 exhibits genomic imprinting in bovine fetal tissues and placenta.

Main Methods:

Analysis of PHLDA2 gene expression across various cattle fetal tissues and developmental stages.
Assessment of allelic expression to confirm monoallelic expression characteristic of imprinting.

Main Results:

PHLDA2 is expressed in a range of cattle fetal tissues and at different developmental stages.
The study provides the first evidence of PHLDA2 as a monoallelically expressed imprinted gene in cattle fetal tissues.
PHLDA2 imprinting was also confirmed in the bovine placenta.

Conclusions:

PHLDA2 is a maternally expressed imprinted gene in cattle, similar to other mammals.
This finding contributes to understanding the role of genomic imprinting in bovine development and placental function.
Further research into PHLDA2's function in cattle may reveal implications for growth and disease.