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Updated: May 23, 2026
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Predicting resting energy expenditure in boys with Duchenne muscular dystrophy
Sarah A Elliott1, Zoe E Davidson, Peter S W Davies
1Children's Nutrition Research Centre, Discipline of Paediatrics and Child Health, The University of Queensland, Royal Children's Hospital, Herston, QLD 4029, Australia.
Background:
Understanding how best to predict energy needs in Duchenne muscular dystrophy (DMD) is fundamental to weight management in clinical practice; however there is a large gap in the literature regarding information on the most appropriate method. We aimed to ascertain the most valid predictive equation that can be used to predict REE in steroid treated ambulatory boys with DMD.
Methods:
REE was measured in 9 boys with DMD using indirect calorimetry after an overnight fast. REE was predicted using five different equations, based on height, weight, or body composition variables.
Results:
Mean measured REE was 5.4 (SD 0.4) MJ/day. The inclusion of fat free mass in the prediction equation provided no benefit over body weight. The exclusion of height, when compared with weight alone, improved predictive performance, as seen with the Schofield equations, in which a minimal bias and root means squared error is seen.
Conclusions:
The most accurate and precise equation was the Schofield weight equation (Bias -0.2 MJ, 95% CI: -1.3-0.9 MJ), which can easily be calculated in a clinical setting and provides a solid foundation from which clinicians can establish energy requirements to support nutritional management in boys with DMD.
