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Prevalence of coeliac disease in healthy blood donors: a study from north India

Rakesh Kochhar1, Suchet Sachdev, Rashi Kochhar

  • 1Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. dr kochhar@hotmail.com

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|April 14, 2012
PubMed

Insights

The prevalence of coeliac disease in apparently healthy blood donors is 0.56%, or 1 in 179 individuals. This finding highlights the utility of blood donor screening for estimating population coeliac disease prevalence.

Area of Science:

  • Gastroenterology
  • Immunology
  • Epidemiology

Background:

  • Coeliac disease diagnosis can be challenging due to asymptomatic cases.
  • Blood donor screening offers a potential method for estimating population coeliac disease prevalence.

Purpose of the Study:

  • To determine the prevalence of coeliac disease in apparently healthy blood donors.
  • To assess the feasibility of using blood donor screening for epidemiological studies of coeliac disease.

Main Methods:

  • Screening of 1610 healthy blood donors for anti-tissue glutaminase antibodies between December 2010 and June 2011.
  • Positive serology cases underwent duodenoscopy for histological confirmation.
  • Demographic and clinical data, including endoscopic findings, were recorded.

Main Results:

  • Nine out of 1610 donors (0.56%) were seropositive for coeliac disease.
  • Histological examination confirmed coeliac disease (Marsh IIIa/IIIb) in all nine positive cases.
  • The estimated prevalence of coeliac disease in this cohort was 1:179, with no significant difference in BMI or hemoglobin compared to the general donor population.

Conclusions:

  • The prevalence of coeliac disease among apparently healthy blood donors is 0.56% (1:179).
  • Blood donor screening is a viable method for estimating coeliac disease prevalence in the general population.
Abstract

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