Oxidative stress in children with attention deficit hyperactivity disorder
Didem Oztop1, Hatice Altun, Gülden Baskol
1Department of Child Psychiatry, Erciyes University School of Medicine, Kayseri, Turkey. dboztop@hotmail.com
Clinical Biochemistry
|April 14, 2012
Summary
Oxidative stress markers malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHDG) were lower in children with attention deficit hyperactivity disorder (ADHD). Antioxidant levels showed no significant difference, suggesting no direct link between oxidative stress and ADHD.
Area of Science:
- Biochemistry
- Pediatrics
- Neuroscience
Background:
- Oxidative stress is implicated in various neurological disorders.
- Its role in attention deficit hyperactivity disorder (ADHD) remains unclear.
Purpose of the Study:
- To investigate potential differences in oxidative stress markers between children with ADHD and healthy controls.
- To assess specific oxidant and antioxidant parameters in pediatric ADHD.
Main Methods:
- Measured malondialdehyde (MDA), 8-hydroxy-2 -deoxyguanosine (8-OHDG), advanced oxidation protein products (AOPP), paraoxonase (PON1), and thiol levels.
- Compared these markers in 30 children diagnosed with ADHD and 30 healthy children (aged 6-12 years).
Main Results:
- ADHD children exhibited significantly lower levels of MDA and 8-OHDG compared to controls.
- No significant differences were observed in AOPP, PON1, or thiol levels between the groups.
Conclusions:
- The study found lower levels of certain oxidants but no difference in antioxidant parameters in children with ADHD.
- These findings suggest that a direct relationship between oxidative stress and ADHD may not exist.
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