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Related Experiment Video

Updated: May 23, 2026

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

Medulloblastoma: progress over time.

Robert I Smee1, Janet R Williams, Katie J De-Loyde

  • 1Department of Radiation Oncology, The Prince of Wales Cancer Centre, Level 2, High Street, Randwick, NSW 2031, Australia.

Journal of Medical Imaging and Radiation Oncology
|April 14, 2012
PubMed
Summary
This summary is machine-generated.

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This pediatric medulloblastoma audit shows survival rates comparable to national averages. Radiotherapy for central nervous system tumors in children yielded similar outcomes across different treatment eras and risk groups.

Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Radiation Oncology

Background:

  • Medulloblastoma is the most common pediatric central nervous system tumor, predominantly affecting children under 16.
  • This study reviews a single center's experience with medulloblastoma treatment.

Purpose of the Study:

  • To audit the outcomes of pediatric medulloblastoma patients treated at a single center.
  • To compare these outcomes with data from other major cancer centers.

Main Methods:

  • Retrospective audit of 80 pediatric patients (<16 years) treated between 1972-2007.
  • Analysis of progression-free survival (PFS) and cancer-specific survival (CSS).
  • Comparison of outcomes based on treatment era (pre- vs. post-1990) and disease risk (high vs. low).

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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
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Published on: October 3, 2010

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Last Updated: May 23, 2026

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

Main Results:

  • The 5-year PFS was 69.7%.
  • 5-year PFS was 66.1% pre-1990 and 71.8% post-1990.
  • 5-year CSS was 61.1% for high-risk and 78.4% for low-risk patients; 33% of patients died from the disease.

Conclusions:

  • Pediatric medulloblastoma patients treated at this center achieved survival rates comparable to those reported by other major institutions.
  • The findings support the effectiveness of the treatment protocols employed.