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Are repeat prostate biopsies safe? A cohort analysis from the SEARCH database.
Ryan P Kopp1, Sean P Stroup, Florian R Schroeck
1Division of Urology, University of California, San Diego, San Diego, California 92103-8897, USA.
The Journal of Urology
|April 14, 2012
Summary
Multiple prostate biopsies do not increase the risk of biochemical recurrence after prostate cancer surgery. These findings suggest that men undergoing multiple biopsies may represent a lower-risk group for recurrence.
Area of Science:
- Urology
- Oncology
- Cancer Research
Background:
- Patient concerns exist regarding the impact of multiple prostate biopsy sessions on prostate cancer outcomes.
- Investigating the association between prior biopsy frequency and post-surgical recurrence is crucial for patient management.
Purpose of the Study:
- To determine if the number of prior prostate biopsy sessions is associated with biochemical recurrence after radical prostatectomy.
- To analyze the relationship between biopsy frequency and prostate cancer outcomes.
Main Methods:
- Analysis of data from the SEARCH database (1988-2010) including men who underwent radical prostatectomy.
- Examined the number of biopsy sessions (1 to 8) as both continuous and categorical variables.
- Utilized Cox proportional hazards models and Kaplan-Meier estimates to assess biochemical recurrence (defined by PSA levels or secondary treatment).
Main Results:
- Of 2,739 men, 82% had 1 biopsy, 13% had 2, and 5% had 3 or more.
- Increased biopsy sessions correlated with higher PSA, larger prostate weight, lower Gleason sum, and more organ-confined disease.
- No association was found between the number of biopsy sessions and biochemical recurrence (continuous or categorical).
- Kaplan-Meier survival estimates for freedom from biochemical recurrence were similar across all biopsy groups.
Conclusions:
- Multiple prostate biopsy sessions are not linked to an increased risk of biochemical recurrence following radical prostatectomy.
- The findings suggest that men requiring multiple biopsies may constitute a lower-risk patient cohort for recurrence.
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