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Small nucleolar RNAs in cancer
Kaiissar Mannoor1, Jipei Liao1, Feng Jiang1
1Department of Pathology, University of Maryland School of Medicine, 10 S, Pine St, Baltimore, MD 21201, USA.
Biochimica Et Biophysica Acta
|April 14, 2012
Summary
Small nucleolar RNAs (snoRNAs) are increasingly recognized for their roles in cancer development. This review highlights their functions in carcinogenesis and potential as cancer biomarkers and therapeutic targets.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Non-coding RNAs (ncRNAs) regulate physiological and cellular processes.
- Alterations in ncRNAs, especially microRNAs, are critical in tumorigenesis.
- Small nucleolar RNAs (snoRNAs), a class of ncRNAs, are increasingly implicated in cancer.
Purpose of the Study:
- To review current research on the functions of snoRNAs in carcinogenesis.
- To explore the potential applications of snoRNAs in cancer diagnosis and therapy.
Main Methods:
- Literature review of studies on snoRNA function in cancer.
- Analysis of differential expression patterns of snoRNAs in human cancers.
- Examination of snoRNA roles in cell transformation, tumorigenesis, and metastasis.
Main Results:
- SnoRNAs are actively involved in carcinogenesis.
- Differential expression of snoRNAs is observed across various human cancers.
- SnoRNAs can influence cell transformation, tumorigenesis, and metastasis.
Conclusions:
- Our understanding of snoRNA functions in cancer development is expanding.
- SnoRNAs hold promise as diagnostic markers and therapeutic targets for cancer.
- Further research is needed to fully elucidate the role of snoRNAs in malignancy.
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