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Published on: February 21, 2018
CD105 and placental growth factor--potent prognostic factors in childhood acute lymphoblastic leukaemia
Patrycja Sujka-Kordowska1, Agnieszka Malinska, Danuta Ostalska-Nowicka
1Department of Histology and Embryology, University of Medical Sciences, Poznan, Poland.
Abstract:
The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytochemical assays respectively. Kaplan-Meier statistics revealed CD105 and PlGF expression as managed separately do not correlate with relapse-free time in ALL patients. On the other hand, an associated analysis of CD105 and PlGF demonstrated a significantly shorter progression-free time in children who were CD105+ and PlGF+ or CD105- and PlGF+ at the moment of ALL diagnosis.
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