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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Related Experiment Video

Updated: May 23, 2026

Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase
09:51

Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase

Published on: June 30, 2023

ATG5, autophagy and lung function in asthma.

Audrey Poon1, David Eidelman, Catherine Laprise

  • 1McGill University Health Centre, Meakins-Christie Laboratories, Montreal, Quebec Canada.

Autophagy
|April 14, 2012
PubMed
Summary
This summary is machine-generated.

Autophagy, a cellular process, is linked to asthma development and severity. This study found genetic links and cellular evidence of autophagy in asthma patients, suggesting its role in lung function decline.

Related Experiment Videos

Last Updated: May 23, 2026

Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase
09:51

Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase

Published on: June 30, 2023

Area of Science:

  • Cellular Biology
  • Respiratory Medicine
  • Genetics

Background:

  • Reactive oxidative species (ROS) are crucial for cell survival but excessive ROS contributes to asthma pathogenesis.
  • Autophagy, a cellular degradation process, is induced by ROS and may play a role in asthma.

Purpose of the Study:

  • To investigate the association between autophagy and asthma pathogenesis.
  • To detect the presence of autophagy using genetic and histological methods.

Main Methods:

  • Genotyping of ATG5 variant rs12212740 in French Canadian and American Caucasian cohorts.
  • Histological examination of bronchial biopsy tissues from asthma patients and healthy subjects to detect autophagosomes.

Main Results:

  • The ATG5 variant rs12212740 was associated with asthma and lung function (FEV1).
  • Autophagosomes were more prevalent in bronchial cells of asthma patients compared to healthy individuals.
  • Asthma is linked to a cytokine environment promoting airway remodeling and lung function loss.

Conclusions:

  • Autophagy is associated with asthma pathogenesis and may contribute to airway remodeling and reduced lung function.
  • Genetic and histological evidence supports autophagy's role in asthma.
  • Autophagy might be a therapeutic target for managing asthma.