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Fixation and Sectioning

Fixation and Sectioning

Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...

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Updated: May 23, 2026

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

Whole-slide imaging: routine pathologic diagnosis.

Toby C Cornish¹, Ryan E Swapp, Keith J Kaplan

¹Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

Advances in Anatomic Pathology

|April 14, 2012

Summary

This summary is machine-generated.

Digital pathology systems, including whole slide imaging (WSI), offer advanced tools for pathologists. While promising for patient care, regulatory and workflow challenges must be addressed for widespread clinical adoption.

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Area of Science:

Digital pathology
Medical imaging
Pathology informatics

Background:

Digital pathology systems provide scalable hardware and software for managing and interpreting pathology information.
Whole slide imaging (WSI) is transitioning from research to clinical applications, mirroring advancements in radiology.

Purpose of the Study:

To review the opportunities and challenges associated with the adoption of digital pathology and WSI in clinical practice.
To identify key areas requiring attention for broader clinical implementation of WSI.

Main Methods:

Review of current digital pathology technologies, including slide scanning, remote viewing, and image analysis.
Analysis of the progress and remaining hurdles for WSI implementation in patient care.

Main Results:

Niche applications of WSI are successful in clinical, educational, and research settings.
Significant challenges remain, including regulatory issues, standardization, validation, and workflow integration.

Conclusions:

Widespread clinical adoption of WSI requires addressing regulatory, standardization, and workflow challenges.
Continued technological advancements and resolution of current issues will drive increased WSI adoption in the next decade, transforming pathology practice.