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Detection of human bocavirus 1 and 2 from children with acute gastroenteritis in Japan

Pattara Khamrin1, Aksara Thongprachum, Hiroyuki Shimizu

  • 1Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Journal of Medical Virology
|April 14, 2012
PubMed

Insights

Human Bocavirus (HBoV) was detected in 6.2% of young children with diarrhea in Japan. Genetic analysis revealed circulation of HBoV 1 and 2A strains during the 2009-2010 season.

Area of Science:

  • Virology
  • Gastroenterology
  • Pediatrics

Background:

  • Human Bocavirus (HBoV) is a recently identified member of the Parvoviridae family.
  • Enteric viral infections are a significant cause of acute gastroenteritis in young children worldwide.

Purpose of the Study:

  • To detect and genetically characterize Human Bocavirus (HBoV) in fecal specimens from Japanese children with diarrhea.
  • To investigate the prevalence and genetic diversity of HBoV in this pediatric population.

Main Methods:

  • Analysis of 177 fecal specimens from children under 5 years old with diarrhea.
  • Nucleotide sequence analysis of detected HBoV strains.
  • Detection of co-infections with other enteric viruses like norovirus and adenovirus.

Main Results:

  • HBoV was detected in 11 (6.2%) of the fecal specimens.
  • Nine cases (81.8%) showed co-infection with other enteric viruses, while two cases (18.2%) had HBoV monoinfection.
  • Sequence analysis identified strains related to HBoV 1 and HBoV 2A, indicating circulation of these types in Japan.

Conclusions:

  • HBoV is an etiological agent associated with acute gastroenteritis in Japanese children.
  • Both HBoV 1 and HBoV 2A genotypes circulated in Japan during the 2009-2010 epidemic season.
  • Co-infection with other enteric viruses is common in HBoV-positive cases.

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