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Biliary-tract cancer in Chile.

I Serra1, A Calvo, M Maturana

  • 1School of Public Health, Faculty of Medicine, University of Chile, Santiago.

International Journal of Cancer
|December 15, 1990
PubMed
Summary

Biliary-tract cancer mortality in Chile significantly increased from 1970 to 1988, particularly affecting young adults and women. A decrease in cholecystectomy rates may be a contributing factor.

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Area of Science:

  • Epidemiology
  • Oncology
  • Public Health

Background:

  • Chile experienced a significant rise in biliary-tract cancer mortality between 1970 and 1988.
  • This increase was observed across all age groups, with a notable impact on young adults (15-44 years) and a persistent 3:1 female-to-male ratio.

Purpose of the Study:

  • To analyze trends in biliary-tract cancer mortality in Chile.
  • To identify potential factors contributing to the observed increase in incidence.

Main Methods:

  • Epidemiological analysis of mortality data from Chile.
  • Age-adjustment using the 1970 world population standard.
  • Comparison of cancer rates across different age groups, genders, and time periods.

Main Results:

  • Biliary-tract cancer mortality rate increased from 5.1 to 12.0 per 100,000 between 1970 and 1988.
  • The rise was pronounced in young women, while in men, it was primarily seen in the elderly.
  • A decrease in cholecystectomy rates was identified as a potential contributing factor, accounting for less than 20% of the mortality increase.

Conclusions:

  • The study highlights an alarming increase in biliary-tract cancer in Chile, necessitating further investigation into causative factors.
  • Potential contributing factors include decreased cholecystectomy rates, increased gallstone prevalence, higher rates of typhoid carriers, and environmental carcinogens.
  • Public health strategies may need to address these emerging risk factors to mitigate the rising cancer incidence.

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