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Related Concept Videos

Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Related Experiment Video

Updated: May 23, 2026

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Research ethics in animal models.

Ivan Dieb Miziara1, Ana Tereza de Matos Magalhães, Maruska d'Aparecida Santos

  • 1Stomatology and Otorhinolaryngology/AIDS Groups of the Otorhinolaryngology Clinical Division, Clinic Hospital, São Paulo University Medical School-FMUSP, SP.

Brazilian Journal of Otorhinolaryngology
|April 14, 2012
PubMed
Summary
This summary is machine-generated.

Animal models are crucial for health advancements. New Brazilian Law 11.794/08 governs animal use in research, requiring otolaryngology researchers to understand ethical guidelines and appropriate animal models.

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Area of Science:

  • Veterinary Medicine
  • Bioethics
  • Otolaryngology Research

Background:

  • The use of animals in scientific research dates back to ancient Greece.
  • Animal models have significantly contributed to medical and health advancements.
  • The ethical considerations surrounding animal use in research remain a persistent debate.

Purpose of the Study:

  • To provide a historical overview of animal research laws.
  • To present current legislation governing animal experimentation.
  • To guide otolaryngology researchers on the ethical use of animal models.

Main Methods:

  • Literature review conducted on the MEDLINE database.
  • Analysis of historical and current legal frameworks for animal research.
  • Examination of studies utilizing animal models in otolaryngology.

Main Results:

  • Brazil previously lacked specific laws for animal experimentation, relying on international standards.
  • Law No. 11.794/08 now regulates the scientific use of animals in Brazil.
  • Otolaryngology studies have employed various animal models, including rabbits, pigs, dogs, guinea pigs, and mice, for research such as rhinoplasty and inner ear studies.

Conclusions:

  • Researchers must be aware of Law 11.794/08 and select appropriate animal models for their studies.
  • Otolaryngologists engaged in research must adhere to ethical principles concerning animal experimentation.
  • Understanding legal and ethical obligations is paramount for responsible animal research.