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Prospective observational study of isoflavone and the risk of stroke recurrence: potential clinical implications

Y-H Chan1, K-K Lau, K-H Yiu

  • 1School of Public Health, The University of Hong Kong, Hong Kong, China.

The Journal of Nutrition, Health & Aging
|April 14, 2012
PubMed

Insights

Higher dietary isoflavone intake in stroke patients was linked to a reduced risk of recurrent stroke and major adverse cardiovascular events (MACE). This suggests isoflavones may offer secondary protection, warranting further investigation.

Area of Science:

  • Cardiovascular Research
  • Nutritional Science
  • Stroke Medicine

Background:

  • The effect of isoflavones on recurrent cardiovascular events remains unclear.
  • Investigating dietary isoflavone intake's role in secondary stroke prevention is crucial.

Purpose of the Study:

  • To examine the association between isoflavone consumption and the risk of stroke recurrence.
  • To assess the relationship between isoflavone intake and major adverse cardiovascular events (MACE) in stroke survivors.

Main Methods:

  • Prospective follow-up of 127 patients with a history of atherothrombotic/hemorrhagic stroke for 30 months.
  • Assessment of stroke recurrence, MACE, brachial flow-mediated dilatation (FMD), and isoflavone intake via food frequency questionnaire.

Main Results:

  • Higher isoflavone intake was independently associated with improved FMD (Pearson R=0.23, p=0.012).
  • Patients with higher isoflavone intake demonstrated significantly longer recurrence-free survival (19.0 vs. 5.0 months, p=0.021) and MACE-free survival (19.0 vs. 4.0 months, p=0.013).
  • Higher isoflavone intake predicted a significantly lower risk of stroke recurrence (HR 0.18, p=0.043) and MACE (HR 0.16, p=0.030).

Conclusions:

  • Increased isoflavone intake in stroke patients correlates with prolonged recurrence-free survival and reduced risk of stroke recurrence and MACE.
  • These protective effects appear independent of baseline vascular function.
  • Randomized controlled trials are needed to confirm if isoflavones provide clinically significant secondary protection in stroke patients.
Abstract

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