Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine Learning to Predict Outcomes of Anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration.

Ophthalmology science·2026
Same author

Spontaneous Branch Retinal Artery Occlusion Secondary to Aneurysmal Fibrosis in an Adult with Coats Disease: A Case Report.

Retinal cases & brief reports·2026
Same author

RetiMap: Automated Retinal Vascular Measures Link Microvascular Structure to Metabolic Health and Predict Cardiovascular Risk.

JACC. Basic to translational science·2026
Same author

Intraocular Pressure Outcomes with Intravitreal Aflibercept 8 mg: A 96-Week Pooled Analysis from PULSAR and PHOTON.

Ophthalmology and therapy·2026
Same author

Artificial intelligence and medical retina training: A scoping review of educational opportunities, emerging risks, and curricular responses.

Survey of ophthalmology·2026
Same author

Insights into age-related macular degeneration.

Handbook of clinical neurology·2026

Related Experiment Video

Updated: May 23, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Differential optical density of subretinal spaces.

Meira Neudorfer1, Amit Weinberg, Anat Loewenstein

  • 1Department of Ophthalmology, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv, Israel.

Investigative Ophthalmology & Visual Science
|April 14, 2012
PubMed
Summary

Optical density ratios in subretinal fluid differ significantly across various retinal diseases, including age-related macular degeneration and diabetic retinopathy. This finding may aid in disease differentiation and treatment strategies.

More Related Videos

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
07:13

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Related Experiment Videos

Last Updated: May 23, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
07:13

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Subretinal fluid (SRF) is a key indicator in several retinal pathologies.
  • Understanding the optical properties of SRF can provide insights into disease mechanisms.

Purpose of the Study:

  • To investigate the optical density characteristics of subretinal fluid (SRF) in various retinal diseases.
  • To assess the potential of optical density ratios (ODRs) in differentiating between conditions such as neovascular age-related macular degeneration (AMD), diabetic retinopathy (DR), and others.

Main Methods:

  • Patients with SRF detected via optical coherence tomography (OCT) were included.
  • Optical density measurements of SRF and vitreous were performed using ImageJ software.
  • Optical density ratios (ODRs) were calculated: SRF OD divided by vitreous OD.

Main Results:

  • Seventy-one patients with diagnoses including AMD, DR, rhegmatogenous retinal detachment (RRD), central serous retinopathy (CSR), retinoschisis (RS), and pseudophakic cystoid macular edema (PCME) were analyzed.
  • ODRs were significantly higher in patients with AMD, DR, CSR, and PCME compared to those with RRD and RS.
  • No significant difference in vitreous reflectivity was observed between these groups.

Conclusions:

  • Disease states significantly alter optical density ratios in subretinal fluid.
  • ODRs show potential for differentiating between retinal disease states.
  • Further research is warranted to explore ODRs for predicting disease outcomes and guiding therapeutic interventions.