Related Experiment Video
Updated: May 23, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
Published on: May 9, 2025
Angiotensinogen gene transcription in pulmonary fibrosis
Bruce D Uhal1, My-Trang T Dang, Xiaopeng Li
1Department of Physiology, Michigan State University, 2201 Biomedical and Physical Sciences Building, East Lansing, MI 48824, USA.
Abstract:
An established body of literature supports the hypothesis that activation of a local tissue angiotensin (ANG) system in the extravascular tissue compartment of the lungs is required for lung fibrogenesis. Transcriptional activation of the angiotensinogen (AGT) gene is believed to be a critical and necessary step in this activation. This paper summarizes the data in support of this theory and discusses transcriptional regulation of AGT, with an emphasis on lung AGT synthesis as a determinant of fibrosis severity. Genetic data linking AGT polymorphisms to the severity of disease in Idiopathic Pulmonary Fibrosis are also discussed.
Related Concept Videos
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Regulation of Angiogenesis and Blood Supply
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Cell Specific Gene Expression
TGF - β Signaling Pathway