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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: May 23, 2026

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

How can microarrays unlock asthma?

Alen Faiz1, Janette K Burgess

  • 1Woolcock Institute of Medical Research, 431 Glebe Point Road, Glebe, NSW 2037, Australia.

Journal of Allergy
|April 14, 2012
PubMed
Summary
This summary is machine-generated.

Gene-expression microarrays reveal underlying asthma mechanisms, offering hope for new treatments. This technology helps identify novel genes and pathways crucial for understanding and treating asthma effectively.

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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Related Experiment Videos

Last Updated: May 23, 2026

Acupuncture in a Rat Model of Asthma
07:14

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Published on: August 25, 2020

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Area of Science:

  • * Genomics and Molecular Biology
  • * Immunology and Respiratory Medicine

Background:

  • * Asthma is a complex respiratory disease with diverse underlying mechanisms.
  • * Current asthma therapies are not effective for all patients, highlighting the need for novel treatments.
  • * Understanding the genetic background of asthma is crucial for developing personalized medicine.

Purpose of the Study:

  • * To review the history and contributions of gene-expression microarray technologies in asthma research.
  • * To explore how these technologies advance our understanding of asthma pathology.
  • * To identify novel genes and pathways involved in asthma.

Main Methods:

  • * Review of scientific literature on gene-expression microarray technologies.
  • * Analysis of studies utilizing microarrays to investigate asthma genetics and pathology.
  • * Historical perspective on the evolution of microarray technology.

Main Results:

  • * Gene-expression microarrays enable rapid identification of numerous genes and pathways.
  • * These technologies have significantly advanced the understanding of asthma's complex mechanisms.
  • * Microarrays facilitate the discovery of potential targets for novel asthma therapies.

Conclusions:

  • * Gene-expression microarrays are powerful tools for unraveling complex diseases like asthma.
  • * Further research using these technologies can lead to more effective and personalized asthma treatments.
  • * Understanding genetic underpinnings is key to overcoming therapeutic resistance in asthma.