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Updated: May 23, 2026
Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Glioblastoma following radiosurgery for meningioma
Hyun Seok Lee1, Jong Hyun Kim, Jung-Il Lee
1Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract:
We report a patient who underwent gamma knife radiosurgery to treat recurrent meningioma after microsurgery and thereafter developed secondary malignancy adjacent to the original tumor. A 47-year-old woman had underwent resection of the olfactory groove meningioma. Then radiosurgery was done three times over 4 year period for the recurrent tumor. After 58 months from the initial radiosurgery, she presented with headache and progressive mental dullness. Huge tumor in bifrontal location was revealed in MRI. Subsequent operation and pathological examination confirmed diagnosis of glioblastoma. This case fits the criteria of radiation-induced tumor and the clinical implication of the issue is discussed.
Insights
A patient developed a secondary glioblastoma after multiple gamma knife radiosurgery treatments for recurrent meningioma. This case highlights the risk of radiation-induced tumors following such interventions.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiation Oncology
Background:
- Meningiomas are primary tumors of the brain's covering.
- Microsurgery is a common treatment for meningioma.
- Gamma knife radiosurgery is used for recurrent or difficult-to-resect tumors.
Observation:
- A 47-year-old woman underwent resection for an olfactory groove meningioma.
- She received three gamma knife radiosurgery treatments over four years for tumor recurrence.
- Fifty-eight months after the first radiosurgery, she developed symptoms of a new, large bifrontal tumor.
Findings:
- Post-operative pathological examination confirmed the new tumor as glioblastoma.
- The glioblastoma was located adjacent to the original tumor site.
- The patient's clinical presentation and tumor characteristics are consistent with radiation-induced secondary malignancy.
Implications:
- This case underscores the potential risk of secondary radiation-induced tumors after gamma knife radiosurgery for meningioma.
- Careful long-term follow-up is crucial for patients treated with radiosurgery.
- The findings warrant consideration of alternative treatment strategies or modified radiation protocols to minimize secondary malignancy risk.
