[Study on the secondary metabolites from the marine sponge Phakellia fusca fungi PF18]

To study the secondary metabolites from the marine sponge Phakellia fusca epiphytic fungi.

The compounds were isolated by column chromatography over silica gel and purified by Sephadex LH-20 column chromatography and preparative TLC. The structures were elucidated by means of physiochemical properties and spectroscopic analyses.

Four compounds were separated and identified as: cyclo-(L-Val-L-Pro) (1), cyclo-(L-Phe-L-Pro) (2), cyclo-(L-Tyr-L-Pro) (3), cyclo-(3-hydroxy-4-methyldecanoyl-Gly-L-Val-D-Leu-L-Ala-L-Phe) (4).

Compounds 1-4 are obtained from the marine sponge Phakellia fusca epiphytic fungi for the first time.