Related Experiment Video
Updated: May 23, 2026

Murine Heterotopic Heart Transplant Technique
Published on: July 8, 2014
Cardiac antibody-mediated rejection
1The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Abstract:
Many factors limit short- and long-term survival after pediatric heart transplantation. Historically, attention had been directed toward T-cell responses and acute cellular rejection. Presence of pretransplant antibodies against HLA is associated with increased donor wait times and poor post-transplant outcomes. Therapies aimed to mitigate circulating antibodies include plasmapheresis, protein A immunoadsorption columns, intravenous immune globulin, rituximab, and bortezomib. The negative effects of B cells, HLA antibodies, and AMR and potential interventions are the focus of this review article.
Related Concept Videos
Cross-reactivity
Hypersensitivity Reactions: Cytolytic Reactions
Cell-mediated Immune Responses
Cardiomyopathy IV: Restrictive Cardiomyopathy
Drug Toxicity: Allergic Reactions
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System