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Related Concept Videos

Glycosaminoglycans01:23

Glycosaminoglycans

Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
Components of...

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Updated: May 23, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

Hyperbranched glycopolymers for blood biocompatibility.

Marya Ahmed1, Benjamin F L Lai, Jayachandran N Kizhakkedathu

  • 1Department of Chemical and Materials Engineering, Alberta Glycomics Centre, University of Alberta , Edmonton, Alberta, Canada.

Bioconjugate Chemistry
|April 17, 2012
PubMed
Summary

New hyperbranched glycopolymers show excellent hemocompatibility for drug delivery. These carbohydrate-based carriers are non-toxic and suitable for biomedical applications, demonstrating a significant advance in biocompatible materials.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Carbohydrate-based carriers are promising for drug and gene delivery due to their non-toxicity and targeting capabilities.
  • Limited understanding exists regarding the blood compatibility of these carbohydrate-based carriers.
  • No prior studies have investigated the hemocompatibility of carbohydrate-based carriers.

Purpose of the Study:

  • To synthesize and characterize hyperbranched glycopolymers of varying molecular weights.
  • To evaluate the in vitro biocompatibility of these glycopolymers, focusing on hemocompatibility and cytotoxicity.
  • To explore the potential of these glycopolymers as blood-compatible drug delivery systems.

Main Methods:

  • Synthesis of hyperbranched glycopolymers using reversible addition-fragmentation chain transfer polymerization (RAFT).
  • Hemocompatibility assessment including hemolysis and platelet activation assays.
  • In vitro cytotoxicity evaluation using cell viability assays on primary and malignant cell lines.

Main Results:

  • Synthesized hyperbranched glycopolymers exhibited high hemocompatibility across varying molecular weights.
  • No significant hemolysis, clot formation, red blood cell aggregation, or immune response was observed.
  • Polymers demonstrated low cytotoxicity against tested cell lines at various concentrations.

Conclusions:

  • Hyperbranched glycopolymers are highly hemocompatible and non-toxic, making them suitable for biomedical applications.
  • These glycopolymers represent excellent candidates for developing advanced drug and gene delivery systems.
  • The study establishes a foundation for the use of glycopolymers in blood-contacting applications.