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Related Experiment Video

Updated: May 23, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Adaptive control of contrast agent microbubbles for shell parameter identification.

Vera Dadok1, Andrew J Szeri

  • 1Department of Mechanical Engineering, University of California, Berkeley, 6112 Etcheverry Hall, Berkeley, California 94720-1740, USA. vdadok@berkeley.edu

The Journal of the Acoustical Society of America
|April 17, 2012
PubMed
Summary
This summary is machine-generated.

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This study introduces an adaptive controller for microbubble systems, enabling precise oscillation control and parameter identification. The novel method non-destructively determines microbubble shell properties for enhanced diagnostic imaging.

Area of Science:

  • Biomedical Engineering
  • Control Systems
  • Acoustic Imaging

Background:

  • Microbubble contrast agents are crucial in diagnostic ultrasound imaging.
  • Accurate characterization of microbubble shell properties is essential for optimizing imaging performance.
  • Existing methods for parameter determination can be invasive or lack precision.

Purpose of the Study:

  • To develop and simulate an adaptive controller for microbubble systems.
  • To achieve precise oscillation control and accurate parameter identification.
  • To enable non-destructive determination of microbubble shell thickness and material properties.

Main Methods:

  • Proposed an adaptive controller design for microbubble systems.
  • Utilized Lyapunov's direct method and Lyapunov-like analysis for stability proofs.

Related Experiment Videos

Last Updated: May 23, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

  • Simulated the controller's performance for trajectory tracking and parameter adaptation.

    • Main Results:

    • Demonstrated the stability and convergence of the proposed adaptive controller.
    • Successfully identified key microbubble parameters, including shell thickness and material properties.
    • Validated the non-destructive nature of the parameter determination method.

    Conclusions:

    • The adaptive controller offers a robust and non-destructive approach for microbubble characterization.
    • This method enhances the potential for real-time parameter estimation in ultrasound imaging.
    • The findings contribute to improved microbubble-based diagnostic and therapeutic applications.