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Updated: May 23, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
TP53 codon 72 polymorphism and risk of acute leukemia
Nageswara Rao Dunna1, Sugunakar Vure, K Sailaja
1School of Chemical and Biotechnology, SASTRA University, Thanjavur, India.
Asian Pacific Journal of Cancer Prevention : APJCP
|April 17, 2012
Summary
The TP53 gene
Area of Science:
- Oncology
- Genetics
Background:
- TP53 is a critical tumor suppressor gene frequently mutated in cancers.
- A common polymorphism at codon 72 of TP53 influences P53 protein function, particularly apoptosis induction.
Purpose of the Study:
- To investigate the association between the TP53 codon 72 polymorphism and the development and prognosis of acute leukemia.
- To analyze the impact of TP53 Arg/Pro genotypes on acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML) outcomes.
Main Methods:
- Genotyping of the TP53 codon 72 polymorphism using PCR-RFLP.
- Analysis of 288 acute leukemia cases (147 ALL, 141 AML) and 245 controls.
- Correlation of genotypes with clinical variables including WBC, blast percentage, LDH levels, and DFS.
Main Results:
- A significant association was found between the homozygous arginine genotype (Arg/Arg) and the development of AML.
- ALL patients with the Arg/Arg genotype showed elevated WBC, blast percentage, LDH, and reduced DFS.
- AML patients with the Pro/Pro genotype exhibited elevated WBC, blast percentage, LDH, and reduced DFS.
Conclusions:
- The Arg/Arg genotype of the TP53 codon 72 polymorphism may increase the risk of developing acute myeloid leukemia.
- The TP53 codon 72 polymorphism appears to influence clinical characteristics and prognosis in both ALL and AML patients.
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