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Associations between adiponectin and two different cancers: breast and colon
Mehmet Ali Gulcelik1, Kadri Colakoglu, Halil Dincer
1General Surgery, Ankara Oncology Training and Research Hospital, Ministry of Health, Ankara, Turkey. mgulcelik@yahoo.com
Asian Pacific Journal of Cancer Prevention : APJCP
|April 17, 2012
Summary
Lower serum adiponectin levels were observed in breast and colon cancer patients compared to controls. This suggests a potential link between low adiponectin and these cancers, warranting further investigation.
Area of Science:
- Oncology
- Metabolic Research
Background:
- Obesity is linked to breast and colon cancer.
- Adiponectin, a protein elevated in obesity, may play a role.
- Limited clinical data exists on adiponectin's role in these cancers.
Purpose of the Study:
- To evaluate serum adiponectin levels in breast and colon cancer patients.
- To assess the relationship between adiponectin levels and clinical factors.
Main Methods:
- Serum adiponectin levels were measured in 87 breast cancer patients and 27 colon cancer patients.
- Levels were compared to controls.
- Associations with BMI, menopausal status, receptor status, and disease stage were assessed.
Main Results:
- Mean serum adiponectin was significantly lower in breast cancer patients (8583 ± 2095 ng/ml) and colon cancer patients (9513 ± 2276 ng/ml) compared to controls (13905 ± 3263 ng/ml).
Conclusions:
- Low serum adiponectin levels may be associated with breast and colon cancer.
- This association was not statistically significant concerning receptor or menopausal status in breast cancer subgroups.
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