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Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos

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Hepatic mucormycosis with abscess formation.

Henry Su¹, George R Thompson, Stuart H Cohen

¹Department of Internal Medicine, University Medical Center, University of California-Davis, Sacramento, CA 95817, USA.

Diagnostic Microbiology and Infectious Disease

|April 17, 2012

Summary

This case study details a rare hepatic mucormycosis with abscess. Surgical intervention, including hepatic segmentectomy, proved effective after initial medical treatments failed.

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Area of Science:

Medicine
Infectious Diseases
Surgical Pathology

Background:

Hepatic mucormycosis is a rare fungal infection, often presenting with high mortality.
Mucormycetes infections typically affect immunocompromised individuals.
Abscess formation in hepatic mucormycosis is an uncommon manifestation.

Observation:

A patient presented with symptoms suggestive of a liver abscess.
Initial diagnostic workup revealed a mucormycetes infection in the liver.
The patient had an uncommon presentation of hepatic mucormycosis with abscess.

Findings:

Standard treatment with transcutaneous pigtail catheter placement, liposomal amphotericin B, and micafungin did not lead to improvement.
Surgical management, including hepatic segmentectomy and hemidiaphragm resection, resulted in patient recovery.
This highlights the potential need for aggressive surgical intervention in refractory cases.

Implications:

Aggressive surgical resection may be a crucial treatment modality for complex hepatic mucormycosis.
Early consideration of surgical options could improve outcomes in similar challenging cases.
Further research into optimal treatment strategies for hepatic mucormycosis is warranted.