Related Experiment Video
Updated: May 23, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Quality of registration for clinical trials published in emergency medicine journals
Christopher W Jones1, Timothy F Platts-Mills
1Department of Emergency Medicine, Christiana Care Hospital, Newark, DE, USA. cjones.unc@gmail.com
Study Objective:
In 2005, the International Committee of Medical Journal Editors established clinical trial registration as a requirement for articles submitted to member journals, with the goal of improving the transparency of clinical research. The objective of this study is to characterize the registration of clinical trials published in emergency medicine journals.
Methods:
Randomized trials involving human subjects and published between June 1, 2008, and May 31, 2011 in the 5 emergency medicine journals with the highest impact factors were included. We assessed the clarity of registered primary outcomes, timing of registration relative to patient enrollment, and consistency between registered and published outcomes.
Results:
Of the 123 trials included, registry entries were identified for 57 (46%). Of the 57 registered studies, 45 (79%) were registered after the initiation of subject enrollment, 9 (16%) had registered outcomes that were unclear, and 26 (46%) had discrepancies between registered and published outcomes. Only 5 studies were registered before patient enrollment with a clear primary outcome that was consistent with the published primary outcome. Annals of Emergency Medicine was the only journal in which the majority of trials were registered.
Conclusion:
Current compliance with clinical trial registration guidelines is poor among trials published in emergency medicine journals.
Related Concept Videos
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Hazard Ratio
For example, in a clinical trial evaluating a...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioavailability Study Design: Healthy Subjects Versus Patients
Clinically Relevant Drug Product Specifications: Methods of Establishment
