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Related Experiment Video

Updated: May 23, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

miRNAs and estrogen action.

Carolyn M Klinge¹

¹Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA. carolyn.klinge@louisville.edu

Trends in Endocrinology and Metabolism: TEM

|April 17, 2012

Summary

MicroRNAs (miRNAs) regulate gene expression influenced by estradiol. Aberrant miRNA expression is linked to estrogen-related cancers, highlighting their role in hormone action and disease.

Area of Science:

Molecular Biology
Genetics
Endocrinology

Background:

MicroRNAs (miRNAs) are short, noncoding RNAs regulating gene expression by targeting messenger RNAs (mRNAs).
Estradiol (E(2)) and estrogen receptor (ER) ligands modulate miRNA expression across various tissues.
Dysregulated miRNA expression is associated with estrogen-dependent cancers like breast and endometrial cancer.

Purpose of the Study:

To explore the role of estrogen-regulated miRNA expression in cellular processes.
To identify target genes regulated by these miRNAs.
To understand the involvement of miRNAs in estrogen action and related diseases.

Main Methods:

Analysis of miRNA expression patterns in response to E(2) and ER ligands.
Bioinformatic prediction and experimental validation of miRNA targets.

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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

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Last Updated: May 23, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

Investigating the functional impact of specific miRNAs on ERα and downstream pathways.

Main Results:

Estradiol influences the expression of specific miRNAs in relevant cell types and tissues.
Several miRNAs have been identified that target and downregulate estrogen receptor alpha (ERα).
These findings suggest a complex regulatory network involving miRNAs in estrogen signaling.

Conclusions:

Estrogen-regulated miRNAs play a significant role in modulating cellular functions and protein expression.
Aberrant miRNA expression contributes to the pathogenesis of estrogen-related cancers.
Further research into estrogen-regulated miRNAs offers potential for novel therapeutic strategies.