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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 23, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Slug expression during melanoma progression.

Stephanie H Shirley1, Victoria R Greene, Lyn M Duncan

  • 1Department of Molecular Carcinogenesis, Science Park, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.

The American Journal of Pathology
|April 17, 2012
PubMed
Summary
This summary is machine-generated.

Slug (Snai2) expression is highest in early melanoma development, not during progression. Its role in melanoma progression may involve interactions with other epithelial-to-mesenchymal transition drivers.

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Area of Science:

  • Oncology
  • Developmental Biology
  • Cell Biology

Background:

  • Slug (Snai2) is a transcription factor involved in epithelial-to-mesenchymal transition (EMT).
  • Slug's role in melanoma progression, particularly in cell adhesion and motility, has been proposed.
  • EMT is crucial for melanocyte development and implicated in melanoma.
  • Microphthalmia-associated transcription factor (MITF) regulates Slug during development.

Purpose of the Study:

  • To investigate Slug expression patterns in melanoma.
  • To determine the relationship between Slug, E-cadherin, and melanoma progression.
  • To elucidate Slug's functional role in melanomagenesis.

Main Methods:

  • Immunohistochemical analysis of melanoma tissue arrays.
  • Comparison of endogenous Slug and E-cadherin expression in melanocytes and melanoma cell lines.
  • In vitro studies of exogenous Slug expression in melanocytes and melanoma cells.
  • Analysis of Slug and MITF expression correlation.

Main Results:

  • Slug expression was higher in nevi than in primary or metastatic melanomas.
  • Slug expression in melanomas did not correlate with decreased E-cadherin.
  • Exogenous Slug expression induced EMT-like changes and stimulated migration/invasion in vitro.
  • Slug expression correlated with MITF expression in tumors and cell lines.

Conclusions:

  • Slug expression is highest during the early stages of melanomagenesis.
  • Persistent Slug expression is not required for melanoma progression.
  • Slug's role in melanoma progression may be context-dependent and involve interactions with other EMT factors like Snail.