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Updated: Aug 12, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
[A proposal for a new histological criteria and staging of non-specific duodenitis (NSD)]
1First Department of Pathology, Niigata University School of Medicine.
Abstract:
Using normal duodenal mucosa (28 cases), initial duodenal ulcer-associated duodenitis (IUAD, 14 cases; 3 active, 8 healing and 3 scarring or healed ulcers) and recurrent duodenal ulcer-associated duodenitis (RUAD, 16 cases; 5 active, 8 healing and 3 scarring or healed ulcers), a new histological criteria and staging of NSD was tried to be made with discriminant analysis. As a result, it is concluded that neutrophilic cell infiltration in the stroma (Ne), gastric superficial epithelial metaplasia (GM), height of villus-crypt unit (HVC) and width of villus (WV) are important factors for histological criteria of NSD, and that number of neutrophilic cells in the stroma (NeS) and percentage of GM in the villus-crypt unit (%GM) are important factors for histological staging of NSD.
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